Endocrine Abstracts

Introduction: The most common cause of Cushing’s disease is ACTH secreting tumours of the pituitary gland. It is associated with high morbidity and mortality. Pasireotide, a potential therapy, has a unique, broad somatostatin-receptor–binding profile, with high binding affinity for somatostatin-receptor subtype 5.Case report: We present the a 40-years-old man diagnosed in 2005 with Cushing’s Disease for which a left adrenalectomy was perfo...

It is known that thyroid pathology is generally more frequently found in women than in men. The somatotroph axis stimulates skeleton growth, but also the development of smooth tissues, including the thyroid gland. We investigated the effect of chronic GH excess upon ultrasound-evaluated (7.5 MHz linear probe) thyroid gland morphology of 74 patients (40 women şi 34 men) diagnosed with acromegaly. When compared to mean thyroid volume of age- and sex-matched non-acromegali...

Introduction: Body weight and lean mass (LM) are classic bone mass determinants. However, the association between total fat mass (FM), regional FM and bone remains controversial, especially as fat is a source of adipocytokines, with both positive and negative bone consequences.Materials and methods: Anthropometric, bone mass (assessed by Dual X-Ray Absorptiometry; DXA) and body composition parameters (assessed by DXA) and also serum adipocytokine (leptin...

Introduction: The prevalence of acromegaly is estimated to be 6-28/100000 but several studies suggest that acromegaly is underdiagnosed and its prevalence is underestimated.Aim: To measure the prevalence of clinically relevant acromegaly in a well-defined population using data from 01.04.2004 to 01.11.2016.Method: Cross-sectional study performed in 8 counties from the North-East Romania. Data of patients with acromegaly were collec...

Introduction: Despite the high burden of osteoporotic fractures, bone evaluation in men is not without flaws, being frequently undervalued. We aimed at investigating the role of body composition, adipokines and classic bone determinants (sex hormones) as predictive factors for bone mass parameters in healthy young and middle-aged men.Materials and methods: Anthropometric, bone mineral density (BMD) (assessed by Dual X-Ray Absorptiometry;DXA) and body com...